Sequence Detail

ID/Version

Q80Z64 Q7TN85 Q6SMR1 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Homeobox protein NANOG;AltName: Full=ES cell-associated protein 4;AltName: Full=Early embryo specific expression NK-type homeobox protein;AltName: Full=Homeobox transcription factor Nanog;

Provider

SWISS-PROT

Sequence

Polypeptide 305 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nanog	Nanog homeobox	82	200	5	26

Sequence references in MGI

J:82040 Wang SH, et al., A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells. Gene Expr Patterns. 2003 Mar;3(1):99-103
J:83420 Mitsui K, et al., The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42
J:83680 Chambers I, et al., Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003 May 30;113(5):643-55
J:90050 Hart AH, et al., Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn. 2004 May;230(1):187-98
J:95814 Hatano SY, et al., Pluripotential competence of cells associated with Nanog activity. Mech Dev. 2005 Jan;122(1):67-79
J:98712 Yamaguchi S, et al., Nanog expression in mouse germ cell development. Gene Expr Patterns. 2005 Jun;5(5):639-646
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107560 Loh YH, et al., The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006 Apr;38(4):431-40
J:111703 Suzuki A, et al., Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10294-9
J:116890 Wu Q, et al., Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem. 2006 Aug 25;281(34):24090-4
J:150360 Nimura K, et al., A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome. Nature. 2009 Jul 9;460(7252):287-91
J:190108 Fidalgo M, et al., Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16202-7
J:190201 Fidalgo M, et al., Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov;29(11):1705-16
J:240273 Zhang X, et al., Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2008 Dec 19;283(51):35825-33
J:242442 Hayashi Y, et al., Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4666-71