Sequence Detail

ID/Version

Q80YA8 A2ALU1 Q6P6N1 (UniProt | EBI)

Last sequence update: 2007-07-24
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein crumbs homolog 2 {ECO:0000305}; Short=crumbs2 {ECO:0000303|PubMed:26496195};AltName: Full=Crumbs-like protein 2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1282 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Crb2	crumbs family member 2	37	102	4	11

Sequence references in MGI

J:177837 Xiao Z, et al., Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn. 2011 Dec;240(12):2646-56
J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
J:227336 Ramkumar N, et al., Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet. 2015 Oct;11(10):e1005551
J:236353 Dudok JJ, et al., Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon. Neurosci Res. 2016 Jul;108:12-23
J:238551 Ramkumar N, et al., Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol. 2016 Dec;18(12):1281-1291
J:296096 Gosens I, et al., FERM protein EPB41L5 is a novel member of the mammalian CRB-MPP5 polarity complex. Exp Cell Res. 2007 Nov 15;313(19):3959-70