Sequence Detail

ID/Version

Q80X41 Q91YH9 O88635 O88636 Q8C2P7 (UniProt | EBI)

Last sequence update: 2003-10-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase VRK1 {ECO:0000305}; EC=2.7.11.1 {ECO:0000269|PubMed:14645249};AltName: Full=Serine/threonine-protein kinase 51PK {ECO:0000303|PubMed:9521809};AltName: Full=Vaccinia-related kinase 1 {ECO:0000303|PubMed

Provider

SWISS-PROT

Sequence

Polypeptide 440 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Vrk1	vaccinia related kinase 1	81	103	3	46

Sequence references in MGI

J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
J:83672 Vega FM, et al., Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003 Jun 5;544(1-3):176-80
J:89002 Nichols RJ, et al., Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004 Feb 27;279(9):7934-46
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:218891 Vinograd-Byk H, et al., The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-beta precursor protein-dependent mechanism. J Neurosci. 2015 Jan 21;35(3):936-42
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:319944 Garcia-Gonzalez R, et al., VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage. Cancers (Basel). 2020 Oct 15;12(10):2986