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Sequence Detail
ID/Version
Q80VM9 Q8BS22 Q8BRZ4 E9QMU2 A0A0R4J1J4 Q7M735 (UniProt | EBI) Last sequence update: 2018-03-28
Last annotation update: 2019-02-13
Sequence
description
from provider
RecName: Full=Proton channel OTOP1 {ECO:0000305};AltName: Full=Otopetrin-1 {ECO:0000303|PubMed:12651873};
Provider SWISS-PROT
Sequence
Polypeptide 600 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Otop1 otopetrin 1 14 7 9 13
Sequence references in MGI J:82639 Hurle B, et al., Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Hum Mol Genet. 2003 Apr 1;12(7):777-89
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:171290 Kim E, et al., Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Mol Cell Neurosci. 2011 Mar;46(3):655-61
J:171566 Kim E, et al., Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. J Neurophysiol. 2010 Dec;104(6):3439-50
J:229138 Wang GX, et al., Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr;63(4):1340-52
J:259123 Tu YH, et al., An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018 Mar 2;359(6379):1047-1050

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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory