Sequence Detail

ID/Version

Q80UE6 Q8R340 Q4VAC1 Q8R0N0 Q80XB5 Q80XN2 A2A4J7 (UniProt | EBI)

Last sequence update: 2003-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase WNK4 {ECO:0000305}; EC=2.7.11.1 {ECO:0000269|PubMed:21486947};AltName: Full=Protein kinase lysine-deficient 4 {ECO:0000312|MGI:MGI:1917097};AltName: Full=Protein kinase with no lysine 4 {ECO:0000303|Pu

Provider

SWISS-PROT

Sequence

Polypeptide 1222 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Wnk4	WNK lysine deficient protein kinase 4	97	101	4	16

Sequence references in MGI

J:84760 Yang CL, et al., WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest. 2003 Apr;111(7):1039-45
J:84958 Wilson FH, et al., Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):680-4
J:113094 Lalioti MD, et al., Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Nat Genet. 2006 Oct;38(10):1124-1132
J:114139 Kahle KT, et al., WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion. Nat Genet. 2003 Dec;35(4):372-6
J:114792 Wilson FH, et al., Human hypertension caused by mutations in WNK kinases. Science. 2001 Aug 10;293(5532):1107-12
J:120059 Ring AM, et al., WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4020-4
J:127376 Yang CL, et al., The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. J Clin Invest. 2007 Nov;117(11):3403-11
J:129716 Yang SS, et al., Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007 May;5(5):331-44
J:152915 Ohta A, et al., Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009 Oct 15;18(20):3978-86
J:172037 Yang D, et al., IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65
J:182953 Chiga M, et al., Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 2011 May 1;124(Pt 9):1391-5
J:197369 Shibata S, et al., Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7838-43
J:279221 Wakabayashi M, et al., Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013 Mar 28;3(3):858-68
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:336068 Dorwart MR, et al., SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol. 2007 Oct 1;584(Pt 1):333-45