Sequence Detail

ID/Version

Q80U87 Q8R0D3 Q80YP2 A2AI53 Q9EQU1 Q9WVP5 (UniProt | EBI)

Last sequence update: 2004-03-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase 8 {ECO:0000305}; EC=3.4.19.12 {ECO:0000269|PubMed:16120644};AltName: Full=Deubiquitinating enzyme 8;AltName: Full=Ubiquitin isopeptidase Y; Short=mUBPy;AltName: Full=Ubiquitin thioesteras

Provider

SWISS-PROT

Sequence

Polypeptide 1080 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Usp8	ubiquitin specific peptidase 8	55	101	3	28

Sequence references in MGI

J:68972 Kato M, et al., A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP. J Biol Chem. 2000 Dec 1;275(48):37481-7
J:72190 Gnesutta N, et al., Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1. J Biol Chem. 2001 Oct 19;276(42):39448-54
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:92790 Wu X, et al., Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol Cell Biol. 2004 Sep;24(17):7748-57
J:107114 Mizuno E, et al., Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes. Mol Biol Cell. 2005 Nov;16(11):5163-74
J:118531 Alwan HA, et al., UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation. J Biol Chem. 2007 Jan 19;282(3):1658-69
J:122732 Niendorf S, et al., Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol. 2007 Jul;27(13):5029-39
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:159711 Berruti G, et al., USP8, a regulator of endosomal sorting, is involved in mouse acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Biol Reprod. 2010 May;82(5):930-9
J:163444 Mizuno E, et al., A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic. 2006 Aug;7(8):1017-31
J:193088 Berruti G, et al., The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells. Biol Reprod. 2005 Jan;72(1):14-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89