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Sequence Detail
ID/Version
Q80U72 Q922S3 Q8CI48 Q7TPH8 Q6P5H7 Q8VII1 Q80VB1 (UniProt | EBI) Last sequence update: 2004-07-19
Last annotation update: 2019-05-08
Sequence
description
from provider
RecName: Full=Protein scribble homolog; Short=Scribble;AltName: Full=Protein LAP4;
Provider SWISS-PROT
Sequence
Polypeptide 1612 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Scrib scribbled planar cell polarity 82 7 7 24
Sequence references in MGI J:81365 Murdoch JN, et al., Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet. 2003 Jan 15;12(2):87-98
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:108647 Montcouquiol M, et al., Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci. 2006 May 10;26(19):5265-75
J:140161 Nola S, et al., Scrib regulates PAK activity during the cell migration process. Hum Mol Genet. 2008 Nov 15;17(22):3552-65
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:152737 Zhan L, et al., Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 2008 Nov 28;135(5):865-78
J:153333 Takizawa S, et al., Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli. Genes Cells. 2006 Apr;11(4):453-64
J:153473 Sun Y, et al., Scribble interacts with beta-catenin to localize synaptic vesicles to synapses. Mol Biol Cell. 2009 Jul;20(14):3390-400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory