Sequence Detail

ID/Version

Q80U63 Q80XK3 Q3V3B8 Q8BHF0 Q8R535 Q923X2 A8Y5E4 Q80WP4 A2A7Y7 Q8BKV5 (UniProt | EBI)

Last sequence update: 2004-05-24
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mitofusin-2; EC=3.6.5.- {ECO:0000250|UniProtKB:O95140};AltName: Full=Hypertension-related protein 1;AltName: Full=Mitochondrial assembly regulatory factor; Short=HSG protein;AltName: Full=Transmembrane GTPase MFN2;

Provider

SWISS-PROT

Sequence

Polypeptide 757 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mfn2	mitofusin 2	79	111	3	19

Sequence references in MGI

J:81438 Chen H, et al., Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003 Jan 21;160(2):189-200
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:198571 Chen Y, et al., PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013 Apr 26;340(6131):471-5
J:200066 Munoz JP, et al., Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J. 2013 Aug 28;32(17):2348-61
J:211366 Yue W, et al., A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 2014 Apr;24(4):482-96
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89