Sequence Detail

ID/Version

Q80TS3 Q80T56 Q504Z9 Q3UM79 Q5HZJ6 Q3UHI7 (UniProt | EBI)

Last sequence update: 2007-01-09
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Adhesion G protein-coupled receptor L3 {ECO:0000305};AltName: Full=Latrophilin-3 {ECO:0000303|PubMed:30792275};AltName: Full=Lectomedin-3 {ECO:0000312|MGI:MGI:2441950};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1537 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrl3	adhesion G protein-coupled receptor L3	69	98	3	18

Sequence references in MGI

J:83410 Vassilatis DK, et al., The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8
J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185872 Wallis D, et al., Initial characterization of mice null for Lphn3, a gene implicated in ADHD and addiction. Brain Res. 2012 Jun 29;1463:85-92
J:211177 O'Sullivan ML, et al., LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5. Neural Dev. 2014;9:7
J:224713 Jackson VA, et al., Structural basis of latrophilin-FLRT interaction. Structure. 2015 Apr 7;23(4):774-81
J:224730 O'Sullivan ML, et al., FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 2012 Mar 8;73(5):903-10
J:225579 Ranaivoson FM, et al., Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development. Structure. 2015 Sep 1;23(9):1665-77
J:272910 Sando R, et al., Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. Science. 2019 Feb 22;363(6429)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:362034 Mathiasen S, et al., G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. Nat Chem Biol. 2020 Dec;16(12):1343-1350
J:362042 Perry-Hauser NA, et al., Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3. J Biol Chem. 2022 Dec;298(12):102594
J:362052 Perry-Hauser NA, et al., N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3. J Biol Chem. 2025 Feb;301(2):108174
J:363100 Wang S, et al., Alternative splicing of latrophilin-3 controls synapse formation. Nature. 2024 Feb;626(7997):128-135