Sequence Detail

ID/Version

Q80TQ2 Q80VB3 Q8BYL9 Q8BXZ3 Q8CGB0 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase CYLD; EC=3.4.19.12 {ECO:0000269|PubMed:32424362};AltName: Full=Deubiquitinating enzyme CYLD;AltName: Full=Ubiquitin thioesterase CYLD;AltName: Full=Ubiquitin-specific-processing protease CYLD;

Provider

SWISS-PROT

Sequence

Polypeptide 952 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyld	CYLD lysine 63 deubiquitinase	138	98	3	19

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108769 Massoumi R, et al., Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 2006 May 19;125(4):665-77
J:112392 Reiley WW, et al., Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006 Apr;7(4):411-7
J:125855 Reiley WW, et al., Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med. 2007 Jun 11;204(6):1475-85
J:136170 Jin W, et al., Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest. 2008 May;118(5):1858-66
J:163064 Wickstrom SA, et al., CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. EMBO J. 2010 Jan 6;29(1):131-44
J:215909 Eguether T, et al., The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 2014;5:4585
J:244164 Wei R, et al., SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes Dev. 2017 Jun 01;31(11):1162-1176
J:262344 Ji YX, et al., The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018 Feb;24(2):213-223
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306372 Mukherjee S, et al., Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation. Nat Immunol. 2020 Jun;21(6):626-635