Sequence Detail

ID/Version

Q80TP3 Q698K9 Q6PEQ8 Q80VL4 Q9CXE9 Q6PFQ9 Q810V6 (UniProt | EBI)

Last sequence update: 2005-09-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase UBR5; EC=2.3.2.26 {ECO:0000269|PubMed:19008229};AltName: Full=E3 ubiquitin-protein ligase, HECT domain-containing 1;AltName: Full=Hyperplastic discs protein homolog {ECO:0000303|PubMed:15282321};

Provider

SWISS-PROT

Sequence

Polypeptide 2792 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ubr5	ubiquitin protein ligase E3 component n-recognin 5	66	97	3	130

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:92269 Saunders DN, et al., Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol Cell Biol. 2004 Aug;24(16):7225-34
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:145887 Tasaki T, et al., The substrate recognition domains of the N-end rule pathway. J Biol Chem. 2009 Jan 16;284(3):1884-95
J:236026 Kinsella E, et al., Use of a Conditional Ubr5 Mutant Allele to Investigate the Role of an N-End Rule Ubiquitin-Protein Ligase in Hedgehog Signalling and Embryonic Limb Development. PLoS One. 2016;11(6):e0157079
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:307316 Mellis D, et al., Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. PLoS Genet. 2021 Apr;17(4):e1009275
J:354162 Tasaki T, et al., A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. Mol Cell Biol. 2005 Aug;25(16):7120-36