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Sequence Detail
Q80SW1 (UniProt | EBI) Last sequence update: 2003-06-01
Last annotation update: 2020-04-22
from provider
RecName: Full=S-adenosylhomocysteine hydrolase-like protein 1;AltName: Full=IP3R-binding protein released with inositol 1,4,5-trisphosphate;AltName: Full=Putative adenosylhomocysteinase 2;AltName: Full=S-adenosyl-L-homocysteine hydrolase 2; Short=
Polypeptide 530 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 31 71 8 7
Sequence references in MGI J:78674 Dekker JW, et al., Identification of an S-adenosylhomocysteine hydrolase-like transcript induced during dendritic cell differentiation. Immunogenetics. 2002 Mar;53(12):993-1001
J:111036 Shirakabe K, et al., IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9542-7
J:144738 Yang D, et al., IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. J Clin Invest. 2009 Jan;119(1):193-202
J:149256 Kiefer H, et al., Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. J Biol Chem. 2009 Apr 17;284(16):10694-705
J:172037 Yang D, et al., IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011 Mar 1;121(3):956-65
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:212812 Ando H, et al., IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding protein, is released from the IP3 receptor upon IP3 binding to the receptor. J Biol Chem. 2003 Mar 21;278(12):10602-12
J:220505 Park S, et al., Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. Gastroenterology. 2013 Jul;145(1):232-41
J:220513 Ando H, et al., An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. J Neurochem. 2009 Apr;109(2):539-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory