Sequence Detail

ID/Version

Q7TS99 (UniProt | EBI)

Last sequence update: 2003-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Hairy and enhancer of split-related protein HELT;AltName: Full=HES/HEY-like transcription factor;AltName: Full=Protein Hes-like;AltName: Full=Protein megane;

Provider

SWISS-PROT

Sequence

Polypeptide 240 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Helt	helt bHLH transcription factor	33	106	3	4

Sequence references in MGI

J:89485 Nakatani T, et al., Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system. J Biol Chem. 2004 Apr 16;279(16):16356-67
J:90073 Miyoshi G, et al., Identification of a novel basic helix-loop-helix gene, Heslike, and its role in GABAergic neurogenesis. J Neurosci. 2004 Apr 7;24(14):3672-82
J:110708 Guimera J, et al., Molecular characterization, structure and developmental expression of Megane bHLH factor. Gene. 2006 Aug 1;377:65-76
J:119562 Guimera J, et al., Megane/Heslike is required for normal GABAergic differentiation in the mouse superior colliculus. Development. 2006 Oct;133(19):3847-57
J:124115 Nakatani T, et al., Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon. Development. 2007 Aug;134(15):2783-93
J:196142 Rardin MJ, et al., Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6