Sequence Detail

ID/Version

Q7TS55 Q80YG2 Q7TNY2 (UniProt | EBI)

Last sequence update: 2003-10-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tumor necrosis factor ligand superfamily member 18;AltName: Full=GITR ligand; Short=GITRL;AltName: Full=Glucocorticoid-induced TNF-related ligand;

Provider

SWISS-PROT

Sequence

Polypeptide 173 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnfsf18	tumor necrosis factor (ligand) superfamily, member 18	48	97	3	13

Sequence references in MGI

J:86980 Tone M, et al., Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15059-64
J:89870 Ji HB, et al., Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J Immunol. 2004 May 15;172(10):5823-7
J:114773 Kim JD, et al., Cloning and characterization of GITR ligand. Genes Immun. 2003 Dec;4(8):564-9
J:131029 Zhou Z, et al., Structural basis for ligand-mediated mouse GITR activation. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):641-5
J:131097 Chattopadhyay K, et al., Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):635-40
J:180483 Yu KY, et al., Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):433-8
J:206613 Liao G, et al., Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine. FASEB J. 2014 Jan;28(1):474-84
J:220504 Lacal PM, et al., Glucocorticoid-induced tumor necrosis factor receptor family-related ligand triggering upregulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and promotes leukocyte adhesion. J Pharmacol Exp Ther. 2013 Oct;347(1):164-72