Sequence Detail

ID/Version

Q7TPH6 Q6PCM8 E9PUJ6 (UniProt | EBI)

Last sequence update: 2018-06-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase MYCBP2 {ECO:0000305}; EC=2.3.2.33 {ECO:0000250|UniProtKB:O75592};AltName: Full=Myc-binding protein 2 {ECO:0000305};AltName: Full=Pam/highwire/rpm-1 protein {ECO:0000303|PubMed:14729956};AltName: Full=Prote

Provider

SWISS-PROT

Sequence

Polypeptide 4749 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mycbp2	MYC binding protein 2, E3 ubiquitin protein ligase	70	101	3	21

Sequence references in MGI

J:87686 Burgess RW, et al., Evidence for a conserved function in synapse formation reveals Phr1 as a candidate gene for respiratory failure in newborn mice. Mol Cell Biol. 2004 Feb;24(3):1096-105
J:125702 Bloom AJ, et al., The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes Dev. 2007 Oct 15;21(20):2593-606
J:132726 Lewcock JW, et al., The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron. 2007 Nov 21;56(4):604-20
J:149890 Saiga T, et al., Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43
J:161386 Yin L, et al., E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11614-9
J:168745 Holland S, et al., The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling. J Biol Chem. 2011 Feb 4;286(5):3671-80
J:177167 Tomsig JL, et al., Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. J Biol Chem. 2003 Mar 21;278(12):10048-54
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:198686 Babetto E, et al., The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Rep. 2013 May 30;3(5):1422-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89