Sequence Detail

ID/Version

Q7TMY8 Q6NS61 Q921M5 Q5BMM7 Q8BNJ7 Q4G2Z1 Q9R0P2 A2AFQ1 Q8CFH2 Q8VD14 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase HUWE1; EC=2.3.2.26 {ECO:0000269|PubMed:18488021};AltName: Full=E3Histone {ECO:0000303|PubMed:15989956};AltName: Full=HECT, UBA and WWE domain-containing protein 1;AltName: Full=HECT-type E3 ubiquitin trans

Provider

SWISS-PROT

Sequence

Polypeptide 4377 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Huwe1	HECT, UBA and WWE domain containing 1	55	99	3	84

Sequence references in MGI

J:86755 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2002 Oct 31;9(5):179-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:145660 Zhao X, et al., The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein. Nat Cell Biol. 2008 Jun;10(6):643-53
J:161386 Yin L, et al., E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11614-9
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:264679 Zhao Z, et al., Hepatic PPARalpha function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology. 2018 Jul;68(1):289-303
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87