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Sequence Detail
Q6ZWX6 Q3TIQ0 (UniProt | EBI) Last sequence update: 2007-01-23
Last annotation update: 2019-02-13
from provider
RecName: Full=Eukaryotic translation initiation factor 2 subunit 1;AltName: Full=Eukaryotic translation initiation factor 2 subunit alpha; Short=eIF-2-alpha; Short=eIF-2A; Short=eIF-2alpha;
Polypeptide 315 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha 43 2 10 66
Sequence references in MGI J:58015 Berlanga JJ, et al., Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. Eur J Biochem. 1999 Oct;265(2):754-62
J:92545 Anthony TG, et al., Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004 Aug 27;279(35):36553-61
J:99455 Harding HP, et al., Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000 Nov;6(5):1099-108
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117281 Timchenko LT, et al., Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. J Biol Chem. 2006 Oct 27;281(43):32806-19
J:129841 Maurin AC, et al., The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. Cell Metab. 2005 Apr;1(4):273-7
J:162904 Yamaji M, et al., Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010 Feb;139(2):381-93
J:227395 Deng J, et al., Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol. 2002 Aug 6;12(15):1279-86

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last database update
MGI 6.14
The Jackson Laboratory