Sequence Detail

ID/Version

Q6Y4S4 Q149Z8 Q80XF6 Q68Y93 (UniProt | EBI)

Last sequence update: 2005-03-01
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Metastasis-suppressor KiSS-1;AltName: Full=Kisspeptin-1;Contains: RecName: Full=Metastin; AltName: Full=Kisspeptin-52;Contains: RecName: Full=Kisspeptin-10; AltName: Full=Metastin45-54;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 130 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kiss1	KiSS-1 metastasis-suppressor	27	110	3	18

Sequence references in MGI

J:83519 Stafford LJ, et al., Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002 Oct 1;62(19):5399-404
J:90608 Terao Y, et al., Expression of KiSS-1, a metastasis suppressor gene, in trophoblast giant cells of the rat placenta. Biochim Biophys Acta. 2004 May 25;1678(2-3):102-10
J:96108 Messager S, et al., Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1761-6
J:122381 d'Anglemont de Tassigny X, et al., Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10714-9
J:145506 Liu X, et al., Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology. 2008 Sep;149(9):4605-14
J:218710 Ahow M, et al., KISS1R signals independently of Galphaq/11 and triggers LH secretion via the beta-arrestin pathway in the male mouse. Endocrinology. 2014 Nov;155(11):4433-46
J:376100 Li Z, et al., Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun. 2024 Feb 12;15(1):1300