Sequence Detail

ID/Version

Q6WQJ1 A8WFL4 Q6ZQ76 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Diacylglycerol lipase-alpha {ECO:0000303|PubMed:26779719}; Short=DAGL-alpha {ECO:0000303|PubMed:26779719}; Short=DGL-alpha {ECO:0000303|PubMed:21183079}; EC=3.1.1.116 {ECO:0000269|PubMed:17584991, ECO:0000269|PubMed:2

Provider

SWISS-PROT

Sequence

Polypeptide 1044 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dagla	diacylglycerol lipase, alpha	54	98	3	20

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:109045 Katona I, et al., Molecular composition of the endocannabinoid system at glutamatergic synapses. J Neurosci. 2006 May 24;26(21):5628-37
J:157850 Gao Y, et al., Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci. 2010 Feb 10;30(6):2017-24
J:167891 Tanimura A, et al., The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010 Feb 11;65(3):320-7
J:197634 Shonesy BC, et al., CaMKII regulates diacylglycerol lipase-alpha and striatal endocannabinoid signaling. Nat Neurosci. 2013 Apr;16(4):456-63
J:222187 Shonesy BC, et al., Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation. Cell Rep. 2014 Dec 11;9(5):1644-53
J:228287 Ogasawara D, et al., Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33
J:229982 Viader A, et al., A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation. Elife. 2016;5:e12345
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:287034 Hsu KL, et al., DAGLbeta inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol. 2012 Dec;8(12):999-1007
J:287705 Jung KM, et al., A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Mol Pharmacol. 2007 Sep;72(3):612-21
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89