Sequence Detail

ID/Version

Q6WKZ8 Q8R0V7 Q8BUL9 Q8CGW0 Q6DIB9 Q8K2I6 Q80U31 Q8R130 (UniProt | EBI)

Last sequence update: 2005-08-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase UBR2; EC=2.3.2.27 {ECO:0000269|PubMed:14585983, ECO:0000269|PubMed:31268597};AltName: Full=N-recognin-2;AltName: Full=Ubiquitin-protein ligase E3-alpha-2 {ECO:0000303|PubMed:15548684};AltName: Full=Ubiquit

Provider

SWISS-PROT

Sequence

Polypeptide 1755 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ubr2	ubiquitin protein ligase E3 component n-recognin 2	56	100	3	18

Sequence references in MGI

J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
J:86438 Kwon YT, et al., Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol. 2003 Nov;23(22):8255-71
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105229 Zenker M, et al., Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome). Nat Genet. 2005 Dec;37(12):1345-50
J:107713 Ouyang Y, et al., Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair. Mutat Res. 2006 Apr 11;596(1-2):64-75
J:109036 An JY, et al., Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6212-7
J:145887 Tasaki T, et al., The substrate recognition domains of the N-end rule pathway. J Biol Chem. 2009 Jan 16;284(3):1884-95
J:157596 An JY, et al., UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1912-7
J:166982 Yang F, et al., The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis. PLoS One. 2010;5(11):e14017
J:243410 Crichton JH, et al., Tex19.1 promotes Spo11-dependent meiotic recombination in mouse spermatocytes. PLoS Genet. 2017 Jul;13(7):e1006904
J:244182 MacLennan M, et al., Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells. Elife. 2017 Aug 14;6:e26152
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306597 Xu H, et al., The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin. EMBO J. 2019 Jul 1;38(13):e101996
J:351183 Shih YC, et al., The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. Nat Commun. 2024 Jan 15;15(1):532