Sequence Detail

ID/Version

Q6T3U4 Q5SVX1 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2023-11-08

Sequence description from provider

RecName: Full=NPC1-like intracellular cholesterol transporter 1 {ECO:0000312|MGI:MGI:2685089};AltName: Full=Niemann-Pick C1-like protein 1 {ECO:0000303|PubMed:14976318, ECO:0000303|PubMed:15671032}; Short=Npc1l1 {ECO:0000303|PubMed:14976318, ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 1333 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Npc1l1	NPC1 like intracellular cholesterol transporter 1	30	96	3	8

Sequence references in MGI

J:89712 Altmann SW, et al., Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4
J:96527 van der Veen JN, et al., Reduced cholesterol absorption upon PPAR{delta} activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res. 2005 Mar;46(3):526-34
J:98568 Davies JP, et al., Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J Biol Chem. 2005 Apr 1;280(13):12710-20
J:121206 Davis HR Jr, et al., Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J Biol Chem. 2004 Aug 6;279(32):33586-92
J:263730 Zhang YY, et al., A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption. Science. 2018 Jun 8;360(6393):1087-1092