Sequence Detail

ID/Version

Q6QLQ4 Q8K1L4 Q9JI50 E9QPW2 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=C-type lectin domain family 7 member A;AltName: Full=Beta-glucan receptor {ECO:0000303|PubMed:11544516};AltName: Full=C-type lectin superfamily member 12;AltName: Full=Dendritic cell-associated C-type lectin 1 {ECO:0000303|PubMed:10779524};

Provider

SWISS-PROT

Sequence

Polypeptide 244 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Clec7a	C-type lectin domain family 7, member a	85	99	2	12

Sequence references in MGI

J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
J:90994 Adachi Y, et al., Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Infect Immun. 2004 Jul;72(7):4159-71
J:96684 Viriyakosol S, et al., Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. 2005 Mar;73(3):1553-60
J:97989 Rogers NC, et al., Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005 Apr;22(4):507-17
J:116669 Taylor PR, et al., Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol. 2007 Jan;8(1):31-8
J:140459 Yadav M, et al., The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood. 2006 Nov 1;108(9):3168-75
J:235794 Kralova J, et al., The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells. J Biol Chem. 2016 Aug 5;291(32):16530-40
J:291457 Campuzano A, et al., CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. J Immunol. 2020 Jun 15;204(12):3296-3306