Sequence Detail

ID/Version

Q6PGN1 E3VWA0 Q8CE11 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Erythroferrone {ECO:0000312|MGI:MGI:3606476};AltName: Full=Complement C1q tumor necrosis factor-related protein 15;AltName: Full=Myonectin {ECO:0000303|PubMed:22351773, ECO:0000303|PubMed:24187137, ECO:0000303|PubMed:34002695};Flags: Precurs

Provider

SWISS-PROT

Sequence

Polypeptide 340 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Erfe	erythroferrone	33	96	3	14

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:185067 Seldin MM, et al., Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012 Apr 6;287(15):11968-80
J:207232 Seldin MM, et al., Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13;288(50):36073-82
J:211331 Kautz L, et al., Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014 Jul;46(7):678-84
J:270227 Arezes J, et al., Erythroferrone inhibits the induction of hepcidin by BMP6. Blood. 2018 Oct 4;132(14):1473-1477
J:291988 Otaka N, et al., Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury. Circ Res. 2018 Dec 7;123(12):1326-1338
J:307104 Castro-Mollo M, et al., The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry. Elife. 2021 May 18;10:e68217
J:335613 Wang CY, et al., Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type Ireceptor ALK3. Blood. 2020;135(6):453-456
J:335614 Stewart AN, et al., Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly. Biochemistry. 2020 Jul 28;59(29):2684-2697