Sequence Detail

ID/Version

Q6PDS3 Q6SZW0 Q8BRI9 Q6A054 Q5SYG6 Q5SYG5 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=NAD(+) hydrolase SARM1 {ECO:0000305}; Short=NADase SARM1 {ECO:0000305}; EC=3.2.2.6 {ECO:0000269|PubMed:28334607};AltName: Full=NADP(+) hydrolase SARM1 {ECO:0000305}; EC=3.2.2.- {ECO:0000250|UniProtKB:Q6SZW1};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 724 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sarm1	sterile alpha and HEAT/Armadillo motif containing 1	68	104	3	15

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:126083 Kim Y, et al., MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J Exp Med. 2007 Sep 3;204(9):2063-74
J:172355 Chen CY, et al., Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. J Cell Biol. 2011 May 16;193(4):769-84
J:185791 Osterloh JM, et al., dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science. 2012 Jul 27;337(6093):481-4
J:200140 Szretter KJ, et al., The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep;83(18):9329-38
J:228171 Gilley J, et al., Absence of SARM1 rescues development and survival of NMNAT2-deficient axons. Cell Rep. 2015 Mar 31;10(12):1974-81
J:252071 Gilley J, et al., Sarm1 Deletion, but Not Wld(S), Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy. Cell Rep. 2017 Oct 3;21(1):10-16
J:256058 Essuman K, et al., The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration. Neuron. 2017 Mar 22;93(6):1334-1343.e5
J:269726 Sasaki Y, et al., NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion. Elife. 2016 Oct 13;5:e19749
J:280444 Cheng Y, et al., Sarm1 Gene Deficiency Attenuates Diabetic Peripheral Neuropathy in Mice. Diabetes. 2019 Nov;68(11):2120-2130
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:294167 Viar K, et al., Sarm1 knockout protects against early but not late axonal degeneration in experimental allergic encephalomyelitis. PLoS One. 2020;15(6):e0235110
J:302470 Ozaki E, et al., SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration. Life Sci Alliance. 2020 May;3(5)