Sequence Detail

ID/Version

Q6PDN3 Q80YN7 Q3TSJ7 Q80YN8 Q924D2 Q80UX0 Q8K026 Q9ERD3 (UniProt | EBI)

Last sequence update: 2006-05-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Myosin light chain kinase, smooth muscle; Short=MLCK; Short=smMLCK; EC=2.7.11.18;AltName: Full=Kinase-related protein; Short=KRP;AltName: Full=Telokin;Contains: RecName: Full=Myosin light chain kinase, smooth

Provider

SWISS-PROT

Sequence

Polypeptide 1941 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mylk	myosin, light polypeptide kinase	49	125	4	13

Sequence references in MGI

J:34055 Herring BP, et al., Telokin expression is mediated by a smooth muscle cell-specific promoter. Am J Physiol. 1996 Jun;270(6 Pt 1):C1656-65
J:68051 Herring BP, et al., Telokin expression is restricted to smooth muscle tissues during mouse development. Am J Physiol Cell Physiol. 2001 Jan;280(1):C12-21
J:70241 Giorgi D, et al., The myosin light chain kinase gene is not duplicated in mouse: partial structure and chromosomal localization of mylk. Genomics. 2001 Jul;75(1-3):49-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101529 Clayburgh DR, et al., Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest. 2005 Oct;115(10):2702-15
J:104789 Ohlmann P, et al., Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function. Am J Physiol Heart Circ Physiol. 2005 Dec;289(6):H2342-9
J:137848 Xu J, et al., Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. Nat Immunol. 2008 Aug;9(8):880-6
J:141907 He WQ, et al., Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology. 2008 Aug;135(2):610-20
J:159758 Zhang WC, et al., Myosin light chain kinase is necessary for tonic airway smooth muscle contraction. J Biol Chem. 2010 Feb 19;285(8):5522-31
J:160318 Yu D, et al., MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8237-41
J:166837 Rogowski K, et al., A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010 Nov 12;143(4):564-78
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:349003 Herring BP, et al., Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle. Am J Physiol Cell Physiol. 2000;279:C1656-C1664