Sequence Detail

ID/Version

Q6P9J9 Q8C242 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Anoctamin-6;AltName: Full=Small-conductance calcium-activated nonselective cation channel; Short=SCAN channel;AltName: Full=Transmembrane protein 16F;

Provider

SWISS-PROT

Sequence

Polypeptide 911 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ano6	anoctamin 6	84	106	3	29

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:138798 Rock JR, et al., Expression of TMEM16 paralogs during murine embryogenesis. Dev Dyn. 2008 Sep;237(9):2566-74
J:165954 Schreiber R, et al., Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45
J:188263 Yang H, et al., TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell. 2012 Sep 28;151(1):111-22
J:190271 Duran C, et al., ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C482-93
J:195901 Ehlen H, Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013;28(2):246-59
J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16
J:276401 Alvadia C, et al., Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. Elife. 2019 Feb 20;8:e44365
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89