Sequence Detail

ID/Version

Q6P1E7 Q8BSR3 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=DNA-directed primase/polymerase protein {ECO:0000303|PubMed:24207056}; EC=2.7.7.102 {ECO:0000269|PubMed:29073063}; EC=2.7.7.7 {ECO:0000250|UniProtKB:Q96LW4};

Provider

SWISS-PROT

Sequence

Polypeptide 537 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Primpol	primase and polymerase (DNA-directed)	72	97	3	19

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203417 Garcia-Gomez S, et al., PrimPol, an Archaic Primase/Polymerase Operating in Human Cells. Mol Cell. 2013 Nov 21;52(4):541-53
J:242620 Pilzecker B, et al., PrimPol prevents APOBEC/AID family mediated DNA mutagenesis. Nucleic Acids Res. 2016 Jun 02;44(10):4734-44
J:285000 Torregrosa-Munumer R, et al., PrimPol is required for replication reinitiation after mtDNA damage. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11398-11403