Sequence Detail

ID/Version

Q6NZQ4 Q9Z0W6 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=PAX-interacting protein 1;AltName: Full=PAX transactivation activation domain-interacting protein;

Provider

SWISS-PROT

Sequence

Polypeptide 1056 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Paxip1	PAX interacting (with transcription-activation domain) protein 1	44	98	3	26

Sequence references in MGI

J:69176 Lechner MS, et al., PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin. Nucleic Acids Res. 2000 Jul 15;28(14):2741-51
J:82319 Cho EA, et al., BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol. 2003 Mar;23(5):1666-73
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:128440 Patel SR, et al., The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007 Oct;13(4):580-92
J:148374 Gong Z, et al., Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009 Mar 13;284(11):7284-93
J:151185 Wu J, et al., PTIP Regulates 53BP1 and SMC1 at the DNA Damage Sites. J Biol Chem. 2009 Jul 3;284(27):18078-84
J:163258 Daniel JA, et al., PTIP promotes chromatin changes critical for immunoglobulin class switch recombination. Science. 2010 Aug 20;329(5994):917-23
J:229465 Starnes LM, et al., A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016 Jan 15;30(2):149-63
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89