Sequence Detail

ID/Version

Q6NZM9 Q3V3Y4 Q3U2J3 Q3TRZ9 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Histone deacetylase 4 {ECO:0000250|UniProtKB:P56524}; Short=HD4; EC=3.5.1.98 {ECO:0000250|UniProtKB:P56524};

Provider

SWISS-PROT

Sequence

Polypeptide 1076 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hdac4	histone deacetylase 4	105	106	3	105

Sequence references in MGI

J:95385 Cao D, et al., Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121892 Berdeaux R, et al., SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 2007 May;13(5):597-603
J:128988 Zhang T, et al., CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses. J Biol Chem. 2007 Nov 30;282(48):35078-87
J:182752 Sasagawa S, et al., SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development. 2012 Mar;139(6):1153-63
J:189792 Rui J, et al., Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation. J Immunol. 2012 Aug 1;189(3):1380-90
J:207816 Kim HN, et al., Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription. J Bone Miner Res. 2011 Sep;26(9):2161-73
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89