Sequence Detail

ID/Version

Q6NXK8 Q50K97 (UniProt | EBI)

Last sequence update: 2004-07-05
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Acid-sensing ion channel 1 {ECO:0000305|PubMed:12843249}; Short=ASIC1 {ECO:0000305|PubMed:12843249};AltName: Full=Acid-sensing ion channel {ECO:0000303|PubMed:11988176};AltName: Full=Amiloride-sensitive cation channel 2, neuronal;Alt

Provider

SWISS-PROT

Sequence

Polypeptide 526 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Asic1	acid-sensing ion channel 1	88	99	5	31

Sequence references in MGI

J:76361 Wemmie JA, et al., The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 2002 Apr 25;34(3):463-77
J:84373 Wemmie JA, et al., Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci. 2003 Jul 2;23(13):5496-502
J:93898 Xiong ZG, et al., Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004 Sep 17;118(6):687-98
J:95099 Page AJ, et al., The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology. 2004 Dec;127(6):1739-47
J:115636 Zha XM, et al., Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16556-61
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:345039 Hoagland EN, et al., Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant. J Biol Chem. 2010 Dec 31;285(53):41852-62