Sequence Detail

ID/Version

Q6GQT6 Q7TNG7 Q6A0A6 Q80UI6 Q6NS67 (UniProt | EBI)

Last sequence update: 2004-07-19
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Sterol regulatory element-binding protein cleavage-activating protein {ECO:0000303|PubMed:9854040}; Short=SCAP {ECO:0000303|PubMed:9854040}; Short=SREBP cleavage-activating protein {ECO:0000303|PubMed:9854040};

Provider

SWISS-PROT

Sequence

Polypeptide 1276 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scap	SREBF chaperone	28	100	3	34

Sequence references in MGI

J:69592 Matsuda M, et al., SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. Genes Dev. 2001 May 15;15(10):1206-16
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:249975 Zhang L, et al., Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. Elife. 2017 Oct 25;6:e28766
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87