Sequence Detail

ID/Version

Q6F3F9 Q811E4 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Adhesion G-protein coupled receptor G6;AltName: Full=Developmentally regulated G-protein-coupled receptor {ECO:0000303|PubMed:15189448};AltName: Full=G-protein coupled receptor 126;Contains: RecName: Full=ADGRG6 N-terminal fragment {ECO:000

Provider

SWISS-PROT

Sequence

Polypeptide 1165 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrg6	adhesion G protein-coupled receptor G6	46	105	3	14

Sequence references in MGI

J:100166 Moriguchi T, et al., DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells. 2004 Jun;9(6):549-60
J:167309 Waller-Evans H, et al., The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010;5(11):e14047
J:173574 Monk KR, et al., Gpr126 is essential for peripheral nerve development and myelination in mammals. Development. 2011 Jul;138(13):2673-80
J:202002 Patra C, et al., Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903
J:204175 Mogha A, et al., Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85
J:219865 Petersen SC, et al., The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 2015 Feb 18;85(4):755-69
J:236616 Kuffer A, et al., The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 2016 Aug 25;536(7617):464-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89