Sequence Detail

ID/Version

Q6F3F9 Q811E4 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Adhesion G-protein coupled receptor G6 {ECO:0000305};AltName: Full=Developmentally regulated G-protein-coupled receptor {ECO:0000303|PubMed:15189448};AltName: Full=G-protein coupled receptor 126 {ECO:0000303|PubMed:21124978};Contains: RecNa

Provider

SWISS-PROT

Sequence

Polypeptide 1165 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adgrg6	adhesion G protein-coupled receptor G6	48	106	3	14

Sequence references in MGI

J:100166 Moriguchi T, et al., DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells. 2004 Jun;9(6):549-60
J:167309 Waller-Evans H, et al., The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010;5(11):e14047
J:173574 Monk KR, et al., Gpr126 is essential for peripheral nerve development and myelination in mammals. Development. 2011 Jul;138(13):2673-80
J:202002 Patra C, et al., Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16898-903
J:204175 Mogha A, et al., Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85
J:218807 Cui H, et al., GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling. J Biol Chem. 2014 Dec 12;289(50):34871-85
J:219865 Petersen SC, et al., The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 2015 Feb 18;85(4):755-69
J:224002 Karner CM, et al., Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice. Hum Mol Genet. 2015 Aug 1;24(15):4365-73
J:236616 Kuffer A, et al., The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 2016 Aug 25;536(7617):464-8
J:237337 Mogha A, et al., Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair. J Neurosci. 2016 Dec 07;36(49):12351-12367
J:287435 Sun P, et al., Regulation of body length and bone mass by Gpr126/Adgrg6. Sci Adv. 2020 Mar;6(12):eaaz0368
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:315981 Torregrosa-Carrion R, et al., Adhesion G protein-coupled receptor Gpr126/Adgrg6 is essential for placental development. Sci Adv. 2021 Nov 12;7(46):eabj5445
J:362021 Kakogiannos N, et al., GPR126 is a specifier of blood-brain barrier formation in the mouse central nervous system. J Clin Invest. 2024 Jun 6;134(15)