Sequence Detail

ID/Version

Q6DVA0 Q8C4H8 Q8R0N2 (UniProt | EBI)

Last sequence update: 2004-08-16
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=LEM domain-containing protein 2;AltName: Full=Nuclear envelope transmembrane protein 25; Short=NET25;

Provider

SWISS-PROT

Sequence

Polypeptide 511 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lemd2	LEM domain containing 2	34	103	1	13

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105608 Brachner A, et al., LEM2 is a novel MAN1-related inner nuclear membrane protein associated with A-type lamins. J Cell Sci. 2005 Dec 15;118(Pt 24):5797-810
J:153986 Huber MD, et al., Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol Cell Biol. 2009 Nov;29(21):5718-28
J:221495 Tapia O, et al., Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:331716 Caravia XM, et al., Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy. J Clin Invest. 2022 Nov 15;132(22)