Sequence Detail

ID/Version

Q69ZR2 (UniProt | EBI)

Last sequence update: 2010-08-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase HECTD1; EC=2.3.2.26 {ECO:0000269|PubMed:22431752};AltName: Full=HECT domain-containing protein 1;AltName: Full=HECT-type E3 ubiquitin transferase HECTD1;AltName: Full=Protein open mind;

Provider

SWISS-PROT

Sequence

Polypeptide 2618 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hectd1	HECT domain E3 ubiquitin protein ligase 1	33	101	3	42

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:122594 Zohn IE, et al., The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol. 2007 Jun 1;306(1):208-21
J:185047 Sarkar AA, et al., Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme. J Cell Biol. 2012 Mar 19;196(6):789-800
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:303313 Lv K, et al., HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis. Cell Stem Cell. 2021 Mar 4;