Sequence Detail

ID/Version

Q69ZK9 Q5F288 (UniProt | EBI)

Last sequence update: 2005-09-13
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Neuroligin-2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 836 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nlgn2	neuroligin 2	105	102	4	14

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:113647 Varoqueaux F, et al., Neuroligins determine synapse maturation and function. Neuron. 2006 Sep 21;51(6):741-54
J:116404 Scheiffele P, et al., Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell. 2000 Jun 9;101(6):657-69
J:127247 Budreck EC, et al., Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci. 2007 Oct;26(7):1738-48
J:134615 Bolliger MF, et al., Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6421-6
J:150416 Hoon M, et al., Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina. J Neurosci. 2009 Jun 24;29(25):8039-50
J:154757 Gibson JR, et al., Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. J Neurosci. 2009 Nov 4;29(44):13883-97
J:154925 Poulopoulos A, et al., Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron. 2009 Sep 10;63(5):628-42
J:155550 Bottos A, et al., The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20782-7
J:175189 Graf ER, et al., Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell. 2004 Dec 29;119(7):1013-26
J:180648 Jedlicka P, et al., Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb Cortex. 2011 Feb;21(2):357-67
J:195216 Pettem KL, et al., Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development. J Cell Biol. 2013 Feb 4;200(3):321-36
J:201532 Woo J, et al., The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. J Cell Biol. 2013 Jun 10;201(6):929-44
J:248265 Koehnke J, et al., Crystal structure of the extracellular cholinesterase-like domain from neuroligin-2. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1873-8
J:256156 Yamasaki T, et al., GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron. 2017 Mar 8;93(5):1138-1152.e6
J:265620 Wu M, et al., Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 2018 May 8;23(6):1691-1705
J:277096 Zhang P, et al., Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018 Sep 6;174(6):1450-1464.e23
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89