Sequence Detail

ID/Version

Q69ZI1 Q8C2T5 Q3UG42 Q8BR66 O70254 Q6P9M8 (UniProt | EBI)

Last sequence update: 2008-05-20
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase SH3RF1; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q7Z6J0};AltName: Full=Plenty of SH3s; Short=Protein POSH {ECO:0000303|PubMed:22959435, ECO:0000303|PubMed:27084103};AltName: Full=RING-type E3 ubiquitin t

Provider

SWISS-PROT

Sequence

Polypeptide 892 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sh3rf1	SH3 domain containing ring finger 1	33	101	3	8

Sequence references in MGI

J:64936 Tapon N, et al., A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 1998 Mar 2;17(5):1395-404
J:86729 Figueroa C, et al., Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex. J Biol Chem. 2003 Nov 28;278(48):47922-7
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:117513 Xu Z, et al., Siah1 interacts with the scaffold protein POSH to promote JNK activation and apoptosis. J Biol Chem. 2006 Jan 6;281(1):303-12
J:205863 Cunningham CA, et al., The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. Eur J Immunol. 2013 Dec;43(12):3361-71
J:261829 Yang T, et al., POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Rep. 2012 Sep 27;2(3):640-51
J:261832 Cunningham CA, et al., POSH Regulates CD4+ T Cell Differentiation and Survival. J Immunol. 2016 May 15;196(10):4003-13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89