Sequence Detail

ID/Version

Q69ZF3 Q6PGM3 Q8BTN9 (UniProt | EBI)

Last sequence update: 2007-04-03
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000305}; Short=NLGase {ECO:0000303|PubMed:23250757}; EC=3.2.1.45 {ECO:0000269|PubMed:17080196};AltName: Full=Beta-glucocerebrosidase 2; Short=Beta-glucosidase 2;AltName: Full=Bil

Provider

SWISS-PROT

Sequence

Polypeptide 918 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gba2	glucosidase beta 2	58	100	3	8

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114991 Yildiz Y, et al., Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility. J Clin Invest. 2006 Nov;116(11):2985-94
J:195545 Korschen HG, et al., The non-lysosomal beta-glucosidase GBA2 is a non-integral membrane-associated protein at the endoplasmic reticulum (ER) and Golgi. J Biol Chem. 2013 Feb 1;288(5):3381-93
J:224223 Raju D, et al., Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics. PLoS Genet. 2015 Mar;11(3):e1005063
J:231478 Marques AR, et al., Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular beta-glucosidases. J Lipid Res. 2016 Mar;57(3):451-63
J:286824 Akiyama H, et al., Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol. J Biol Chem. 2020 Apr 17;295(16):5257-5277
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89