Sequence Detail

ID/Version

Q69Z66 Q8C4N1 A2AJE3 B9EKJ6 Q3TPV7 Q8BRP5 (UniProt | EBI)

Last sequence update: 2006-05-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Deubiquitinase MYSM1; Short=2A-DUB; EC=3.4.19.- {ECO:0000269|PubMed:26474655};AltName: Full=Myb-like, SWIRM and MPN domain-containing protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 819 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mysm1	myb-like, SWIRM and MPN domains 1	51	98	3	16

Sequence references in MGI

J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:179287 Jiang XX, et al., Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1. Immunity. 2011 Dec 23;35(6):883-96
J:202315 Nandakumar V, et al., Epigenetic control of natural killer cell maturation by histone H2A deubiquitinase, MYSM1. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3927-36
J:218684 Won H, et al., Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1. Blood. 2014 Oct 23;124(17):2647-56
J:233920 Panda S, et al., Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. Immunity. 2015 Oct 20;43(4):647-59
J:251591 Jiang XX, et al., Epigenetic Regulation of Antibody Responses by the Histone H2A Deubiquitinase MYSM1. Sci Rep. 2015 Sep 8;5:13755
J:267514 Panda S, et al., The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018 Nov 7;9(1):4654
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:299946 Tian M, et al., MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway. Cell Rep. 2020 Oct 20;33(3):108297
J:302873 Forster M, et al., MYSM1-dependent checkpoints in B cell lineage differentiation and B cell-mediated immune response. J Leukoc Biol. 2017 Mar;101(3):643-654