Sequence Detail

ID/Version

Q68G58 Q9CS12 Q8BYE9 Q8R328 Q8R018 Q8BJP7 Q8BUZ2 Q8BTR7 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=DNA-(apurinic or apyrimidinic site) endonuclease 2; EC=3.1.11.2 {ECO:0000250|UniProtKB:Q9UBZ4};AltName: Full=APEX nuclease 2;AltName: Full=Apurinic-apyrimidinic endonuclease 2; Short=AP endonuclease 2;

Provider

SWISS-PROT

Sequence

Polypeptide 516 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Apex2	apurinic/apyrimidinic endonuclease 2	33	96	3	11

Sequence references in MGI

J:82005 Ide Y, et al., Characterization of the genomic structure and expression of the mouse Apex2 gene( small star, filled ). Genomics. 2003 Jan;81(1):47-57
J:95267 Ide Y, et al., Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 2004 Dec 15;104(13):4097-103
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:128500 Guikema JE, et al., APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med. 2007 Nov 26;204(12):3017-26
J:151678 Sabouri Z, et al., Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. Int Immunol. 2009 Aug;21(8):947-55