Sequence Detail

ID/Version

Q68FF6 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=ARF GTPase-activating protein GIT1; Short=ARF GAP GIT1;AltName: Full=G protein-coupled receptor kinase-interactor 1;AltName: Full=GRK-interacting protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 770 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Git1	GIT ArfGAP 1	75	97	3	26

Sequence references in MGI

J:120748 Segura I, et al., Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nat Neurosci. 2007 Mar;10(3):301-10
J:141061 Angrand PO, et al., Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics. 2006 Dec;5(12):2211-27
J:150460 Schmalzigaug R, et al., Impaired fear response in mice lacking GIT1. Neurosci Lett. 2009 Jul 17;458(2):79-83
J:158848 Menon P, et al., Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 4;1317:218-26
J:158935 Pang J, et al., G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation. 2009 Mar 24;119(11):1524-32
J:171608 Won H, et al., GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice. Nat Med. 2011 May;17(5):566-72
J:205503 Fiuza M, et al., GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20807-12
J:213433 Yin G, et al., Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice. PLoS One. 2014;9(2):e89127
J:217270 Hagemann N, et al., The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene. 2013 Sep 26;32(39):4602-13
J:259711 Martyn AC, et al., GIT1 regulates synaptic structural plasticity underlying learning. PLoS One. 2018;13(3):e0194350
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297321 Hong ST, et al., A Critical Role of GIT1 in Vertebrate and Invertebrate Brain Development. Exp Neurobiol. 2015 Mar;24(1):8-16
J:297330 Zhao SJ, et al., Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way. J Bone Miner Res. 2020 Oct;35(10):2015-2031
J:319812 Badea A, et al., Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. Magn Reson Imaging. 2021 Feb;76:26-38
J:319814 Li L, et al., GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-kappaB/Notch signalling to promote angiogenesis. Cell Prolif. 2019 Nov;52(6):e12689