Sequence Detail

ID/Version

Q66T02 Q66T00 Q6ZQ62 A2A8B7 A2A8B6 Q6P3B1 Q8R571 (UniProt | EBI)

Last sequence update: 2004-10-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Pleckstrin homology domain-containing family G member 5; Short=PH domain-containing family G member 5;AltName: Full=Synectin-binding RhoA exchange factor; Short=SYX;

Provider

SWISS-PROT

Sequence

Polypeptide 1073 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	32	98	4	60

Sequence references in MGI

J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:112471 Liu M, et al., A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Mol Biol Cell. 2006 Apr;17(4):1880-7
J:200496 Wu C, et al., Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem. 2011 Jul 1;286(26):23511-20
J:201081 Azzedine H, et al., PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease. Hum Mol Genet. 2013 Oct 15;22(20):4224-32
J:252982 Luningschror P, et al., Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nat Commun. 2017 Oct 30;8(1):678
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89