Sequence Detail

ID/Version

Q64455 Q3UHL5 Q8CIW9 Q541R5 Q3UH64 Q8K3Q2 (UniProt | EBI)

Last sequence update: 2009-12-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor-type tyrosine-protein phosphatase eta; Short=Protein-tyrosine phosphatase eta; Short=R-PTP-eta; EC=3.1.3.48;AltName: Full=HPTP beta-like tyrosine phosphatase;AltName: Full=Protein-tyrosine phosphatase recepto

Provider

SWISS-PROT

Sequence

Polypeptide 1238 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ptprj	protein tyrosine phosphatase receptor type J	111	100	5	24

Sequence references in MGI

J:30550 Kuramochi S, et al., Molecular cloning and characterization of Byp, a murine receptor-type tyrosine phosphatase similar to human DEP-1. FEBS Lett. 1996 JAN 2;378(1):7-14
J:50896 Osborne JM, et al., Murine DEP-1, a receptor protein tyrosine phosphatase, is expressed in macrophages and is regulated by CSF-1 and LPS. J Leukoc Biol. 1998 Nov;64(5):692-701
J:77487 Ruivenkamp CA, et al., Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat Genet. 2002 Jul;31(3):295-300
J:82356 Takahashi T, et al., A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol. 2003 Mar;23(5):1817-31
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131736 Zhu JW, et al., Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling. Immunity. 2008 Feb;28(2):183-96
J:148960 Senis YA, et al., The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood. 2009 May 14;113(20):4942-54
J:150385 Dave RK, et al., CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages. Exp Cell Res. 2009 Jun 10;315(10):1734-44
J:169796 Lin J, et al., The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J Cell Biol. 2003 Aug 18;162(4):673-82
J:169797 Jandt E, et al., The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell-matrix adhesion. Oncogene. 2003 Jul 3;22(27):4175-85
J:169798 Grazia Lampugnani M, et al., Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol. 2003 May 26;161(4):793-804
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89