Sequence Detail

ID/Version

Q64430 Q64431 A2AG69 O35101 P97422 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Copper-transporting ATPase 1; EC=7.2.2.8 {ECO:0000250|UniProtKB:Q04656};AltName: Full=Copper pump 1;AltName: Full=Menkes disease-associated protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 1491 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp7a	ATPase, Cu++ transporting, alpha polypeptide	176	112	3	110

Sequence references in MGI

J:17492 Levinson B, et al., The mottled gene is the mouse homologue of the Menkes disease gene [see comments]. Nat Genet. 1994 Apr;6(4):369-73
J:17493 Mercer JF, et al., Mutations in the murine homologue of the Menkes gene in dappled and blotchy mice [see comments]. Nat Genet. 1994 Apr;6(4):374-8
J:41388 Grimes A, et al., Molecular basis of the brindled mouse mutant (Mo(br)): a murine model of Menkes disease. Hum Mol Genet. 1997 Jul;6(7):1037-42
J:46349 Ohta Y, et al., Occurrence of two missense mutations in Cu-ATpase of the macular mouse, a menkes disease model. Biochem Mol Biol Int. 1997 NOV;43(4):913-918
J:81409 Steveson TC, et al., Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Endocrinology. 2003 Jan;144(1):188-200
J:97021 Schlief ML, et al., NMDA receptor activation mediates copper homeostasis in hippocampal neurons. J Neurosci. 2005 Jan 5;25(1):239-46
J:105736 Qin Z, et al., Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress. FASEB J. 2006 Feb;20(2):334-6
J:139015 Setty SR, et al., Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature. 2008 Aug 28;454(7208):1142-6
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:221066 Hodgkinson VL, et al., X-linked spinal muscular atrophy in mice caused by autonomous loss of ATP7A in the motor neuron. J Pathol. 2015 Jun;236(2):241-50
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:302464 Zhu S, et al., Multiple di-leucines in the ATP7A copper transporter are required for retrograde trafficking to the trans-Golgi network. Metallomics. 2016 Sep 1;8(9):993-1001