Sequence Detail

ID/Version

Q64374 A2AFC8 Q3UJG3 Q60944 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Regucalcin; Short=RC;AltName: Full=Gluconolactonase; Short=GNL; EC=3.1.1.17;AltName: Full=Senescence marker protein 30; Short=SMP-30;

Provider

SWISS-PROT

Sequence

Polypeptide 299 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rgn	regucalcin	49	101	3	5

Sequence references in MGI

J:34548 Fujita T, et al., Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30). Biochim Biophys Acta. 1996 Jul 31;1308(1):49-57
J:43120 Murata T, et al., Molecular cloning of the cDNA coding for regucalcin and its mRNA expression in mouse liver: the expression is stimulated by calcium administration. Mol Cell Biochem. 1997 Aug;173(1-2):127-33
J:88791 Ishigami A, et al., SMP30 deficiency in mice causes an accumulation of neutral lipids and phospholipids in the liver and shortens the life span. Biochem Biophys Res Commun. 2004 Mar 12;315(3):575-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108295 Kondo Y, et al., Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5723-8
J:195848 Aizawa S, et al., Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase. PLoS One. 2013;8(1):e53706
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89