Sequence Detail

ID/Version

Q64287 Q60802 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Interferon regulatory factor 4; Short=IRF-4;AltName: Full=Lymphocyte-specific interferon regulatory factor {ECO:0000303|PubMed:7541907}; Short=LSIRF;AltName: Full=NF-EM5;AltName: Full=PU.1 interaction partner;AltName: Full=Tr

Provider

SWISS-PROT

Sequence

Polypeptide 450 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irf4	interferon regulatory factor 4	76	107	5	20

Sequence references in MGI

J:26104 Eisenbeis CF, et al., Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev. 1995 Jun 1;9(11):1377-87
J:30565 Matsuyama T, et al., Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res. 1995 Jun 25;23(12):2127-36
J:165281 Biswas PS, et al., Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest. 2010 Sep 1;120(9):3280-95
J:188767 Tussiwand R, et al., Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012 Oct 25;490(7421):502-7
J:189230 Li P, et al., BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012 Oct 25;490(7421):543-6
J:190118 Glasmacher E, et al., A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16;338(6109):975-80
J:224866 Bruchard M, et al., The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015 Aug;16(8):859-70
J:361874 Fornes O, et al., A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency. Sci Immunol. 2023 Jan 20;8(79):eade7953