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Sequence Detail
Q64279 Q61099 (UniProt | EBI) Last sequence update: 1996-11-01
Last annotation update: 2019-05-08
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RecName: Full=Heart- and neural crest derivatives-expressed protein 1;AltName: Full=Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1; Short=eHAND;AltName: Full=Helix-loop-helix transcription
Polypeptide 216 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Hand1 heart and neural crest derivatives expressed 1 66 71 7 14
Sequence references in MGI J:26206 Hollenberg SM, et al., Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol. 1995 Jul;15(7):3813-22
J:28009 Cross JC, et al., Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23
J:28312 Cserjesi P, et al., Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol. 1995 Aug;170(2):664-78
J:46383 Riley P, et al., The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet. 1998 Mar;18(3):271-5
J:113904 Firulli BA, et al., The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem. 2000 Oct 27;275(43):33567-73
J:152657 Martindill DM, et al., Nucleolar release of Hand1 acts as a molecular switch to determine cell fate. Nat Cell Biol. 2007 Oct;9(10):1131-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory