Sequence Detail

ID/Version

Q64264 Q60956 Q8BGS4 Q61617 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=5-hydroxytryptamine receptor 1A; Short=5-HT-1A; Short=5-HT1A;AltName: Full=Serotonin receptor 1A;

Provider

SWISS-PROT

Sequence

Polypeptide 421 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	63	103	4	17

Sequence references in MGI

J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
J:16036 Charest A, et al., Cloning and differentiation-induced expression of a murine serotonin1A receptor in a septal cell line. J Neurosci. 1993 Dec;13(12):5164-71
J:31460 Parks CL, et al., The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. J Biol Chem. 1996 Feb 23;271(8):4417-30
J:51280 Ramboz S, et al., Serotonin receptor 1A knockout: an animal model of anxiety-related disorder [see comments]. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14476-81
J:65662 Ase AR, et al., Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice. J Neurochem. 2000 Dec;75(6):2415-26
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124043 Deng DR, et al., Embryonic and postnatal development of the serotonergic raphe system and its target regions in 5-HT1A receptor deletion or overexpressing mouse mutants. Neuroscience. 2007 Jun 29;147(2):388-402
J:137439 Audero E, et al., Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science. 2008 Jul 4;321(5885):130-3
J:171605 Richardson-Jones JW, et al., Serotonin-1A Autoreceptors Are Necessary and Sufficient for the Normal Formation of Circuits Underlying Innate Anxiety. J Neurosci. 2011 Apr 20;31(16):6008-6018