Sequence Detail

ID/Version

Q64253 Q99JA5 Q61128 (UniProt | EBI)

Last sequence update: 2020-12-02
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Lymphocyte antigen 6E {ECO:0000305}; Short=Ly-6E;AltName: Full=Stem cell antigen 2;AltName: Full=Thymic shared antigen 1; Short=TSA-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 136 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ly6e	lymphocyte antigen 6 family member E	20	106	2	18

Sequence references in MGI

J:16061 MacNeil I, et al., Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development. J Immunol. 1993 Dec 15;151(12):6913-23
J:18702 Classon BJ, et al., Mouse stem cell antigen Sca-2 is a member of the Ly-6 family of cell surface proteins. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5296-300
J:34487 Classon BJ, et al., Genomic organization and expression of mouse thymic shared antigen-1 (TSA-1): evidence for a processed pseudogene. Immunogenetics. 1996;44(3):222-6
J:73972 Zammit DJ, et al., Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. Mol Cell Biol. 2002 Feb;22(3):946-52
J:225865 Wu M, et al., Mechanisms of Inhibition and Potentiation of alpha4beta2 Nicotinic Acetylcholine Receptors by Members of the Ly6 Protein Family. J Biol Chem. 2015 Oct 2;290(40):24509-18
J:253345 Bacquin A, et al., A Cell Fusion-Based Screening Method Identifies Glycosylphosphatidylinositol-Anchored Protein Ly6e as the Receptor for Mouse Endogenous Retroviral Envelope Syncytin-A. J Virol. 2017 Sep 15;91(18)
J:263810 Langford MB, et al., Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Sci Rep. 2018 Mar 2;8(1):3961
J:291868 Pfaender S, et al., LY6E impairs coronavirus fusion and confers immune control of viral disease. Nat Microbiol. 2020 Jul 23;
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89