Sequence Detail

ID/Version

Q64127 Q64126 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription intermediary factor 1-alpha; Short=TIF1-alpha; EC=2.3.2.27;AltName: Full=E3 ubiquitin-protein ligase Trim24;AltName: Full=RING-type E3 ubiquitin transferase TIF1-alpha {ECO:0000305};AltName: Full=Tripartite moti

Provider

SWISS-PROT

Sequence

Polypeptide 1051 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trim24	tripartite motif-containing 24	91	107	3	38

Sequence references in MGI

J:25214 LeDouarin B, et al., The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 1995 May 1;14(9):2020-33
J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
J:111226 Torres-Padilla ME, et al., Role of TIF1{alpha} as a modulator of embryonic transcription in the mouse zygote. J Cell Biol. 2006 Jul 31;174(3):329-38
J:118800 Zhong S, et al., A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999 Nov;23(3):287-95
J:129617 Laz EV, et al., Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology. 2007 Jul;148(7):3327-37
J:130210 Khetchoumian K, et al., Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007 Dec;39(12):1500-6
J:132781 Ignat M, et al., Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2598-603
J:150816 Allton K, et al., Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11612-6
J:164828 Kikuchi M, et al., TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. Biochim Biophys Acta. 2009 Dec;1793(12):1828-36
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87