Sequence Detail

ID/Version

Q64092 A2AEW4 Q3U8H0 Q3UT52 Q3UMV4 Q8BN29 A2AEW3 Q7TNC1 (UniProt | EBI)

Last sequence update: 2007-01-09
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor E3 {ECO:0000303|PubMed:1732746}; Short=mTFE3 {ECO:0000303|PubMed:1732746};

Provider

SWISS-PROT

Sequence

Polypeptide 572 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tfe3	transcription factor E3	53	107	4	45

Sequence references in MGI

J:2609 Roman C, et al., mTFE3, an X-linked transcriptional activator containing basic helix-loop-helix and zipper domains, utilizes the zipper to stabilize both DNA binding and multimerization. Mol Cell Biol. 1992 Feb;12(2):817-27
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112628 Huan C, et al., Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Nat Immunol. 2006 Oct;7(10):1082-1091
J:196261 Hong SB, et al., Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization. PLoS One. 2010;5(12):e15793
J:201276 Betschinger J, et al., Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell. 2013 Apr 11;153(2):335-47
J:274781 Willett R, et al., TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. Nat Commun. 2017 Nov 17;8(1):1580
J:285017 Wada S, et al., The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016 Nov 15;30(22):2551-2564
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:338157 Kato M, et al., Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-beta-induced collagen expression in kidney cells. J Biol Chem. 2010 Oct 29;285(44):34004-15